Key result
Anti-MOG antibody disease can present atypically as acute flaccid, areflexic paralysis, overlapping clinically with post-infectious acute flaccid myelitis and Guillain-Barre syndrome.
Why the study?
Anti-MOG antibody positivity is primarily linked with ADEM, optic neuritis, and transverse myelitis, but presentations with acute flaccid paralysis that overlap with post-infectious acute flaccid myelitis and Guillain-Barre syndrome remain poorly recognized.
Case Report (n=2)
Anti-MOG antibody disease should be considered in the differential diagnosis for children presenting with acute flaccid paralysis.
Answers are grounded in this paper and cite their sources.
Supports considering anti-MOG in pediatric acute flaccid paralysis differentials; hypothesis-generating pending larger studies.
Anti-Myelin Oligodendrocyte Glycoprotein (MOG) antibody positivity has been primarily associated with acute disseminated encephalomyelitis (ADEM), optic neuritis, transverse myelitis, and less commonly with aseptic meningitis and seizures. We report two children with clinical syndromes of flaccid, areflexic paralysis who were found to have anti-MOG related myelitis. Physical examination, imaging, laboratory results, treatment and clinical course are described. This report highlights this important manifestation of MOG antibody disease which overlaps clinically with other syndromes including post-infectious acute flaccid myelitis and Guillain-Barre syndrome.
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Khan et al. (2022) conducted a case report in Anti-Myelin Oligodendrocyte Glycoprotein (MOG) antibody disease (n=2). Anti-MOG antibody disease was evaluated on Clinical presentation and course. Anti-MOG antibody disease can present atypically as acute flaccid, areflexic paralysis, overlapping clinically with post-infectious acute flaccid myelitis and Guillain-Barre syndrome.
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