Three new diketopiperazine-containing metabolites 1-3 have been isolated from the sclerotia of Aspergillus ochraceus (NRRL 3519) by chromatography on Sephadex LH-20 and reversed-phase hplc. The structures of these compounds were established using extensive high-field 1D and 2D nmr experiments. All three compounds cause moderate reduction in weight gain in assays against the lepidopteran crop pest Helicoverpa zea.
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Guzman et al. (1992) studied this question.