Key result
A single 2.4 g dose of aged garlic extract did not change cerebral oxygenation, blood volume, or nitrite levels in older adults with cardiovascular risk factors.
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Why the study?
Ageing impairs endothelial function and can negatively affect cerebral blood flow, raising the question of whether aged garlic extract could improve cerebral oxygenation and blood volume via potential vasoactive effects.
Does a single dose of aged garlic extract improve cerebral oxygenation and blood volume in older adults with cardiovascular risk factors?
RCT (n=14)
Double-blind
cross-over
Does a single dose of aged garlic extract improve cerebral oxygenation and blood volume in older adults with cardiovascular risk factors?
A single 2.4 g dose of aged garlic extract does not improve cerebral hemodynamics or nitrite levels in older adults with cardiovascular risk factors.
Single-dose aged garlic extract yields no acute cerebral hemodynamic benefit; confirms lack of effect on oxygenation, volume, or nitrite in older adults with CV risk.
Background and Aims: Ageing is associated with impaired endothelial function , which can negatively affect cerebral blood flow (CBF). The present study evaluated whether aged garlic extract (AGE) could improve cerebral oxygenation and blood volume due to the possible vasoactive effect. Methods and Results: Fourteen older adults were enrolled in a randomized, double-blind, cross-over study. Urinary thiosulfate and plasma nitrite was drawn, and participants ingested 2.4 g of AGE or placebo. A handgrip exercise protocol started 180 min after supplementation to induce brain activation , and cerebral oxygenation and blood volume were evaluated by near-infrared spectroscopy. After exercise, urinary thiosulfate and plasma nitrite were re-evaluated. AGE supplementation did not change cerebral oxygenation and blood volume. In addition, urinary thiosulfate and plasma nitrite remained unchanged after supplementation. Conclusion: A single dose of AGE (2.4 g) could not increase nitrite levels and cerebral oxygenation and blood volume in older adults at cardiovascular risk factors (NCT04008693).
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Volino‐Souza et al. (2023) conducted an RCT in cardiovascular risk factors (n=14). aged garlic extract (AGE) vs. placebo was evaluated on cerebral oxygenation and blood volume. A single 2.4 g dose of aged garlic extract did not change cerebral oxygenation, blood volume, or nitrite levels in older adults with cardiovascular risk factors.
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