Synthesis and X‐ray Structure of a Shape‐Persistent Macrocyclic Amphiphile

A rigid molecular framework with hydrophilic and hydrophobic substituents is found in the macrocyclic amphiphile 1, which can be prepared in gram quantities. An X-ray structure determination of crystals of 1 obtained from pyridine shows that the polar phenoxy groups point toward the outside and that the macrocycle has a hydrophobic interior.