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Chemical synthesis study demonstrates direct electrochemical alkylation of imines using alkyl halides, suggesting a sustainable, reagent-free route for drug synthesis.
An electrochemical protocol for the alkylation of imines was developed by using easily available alkyl halides as the alkyl sources, graphite felt (GF) as anode and zinc plate as cathode. Various substituted imines, alkyl bromides and alkyl iodides were suitable for this reaction and a series of α‐branched amines were obtained in moderate to good yields. This method provides a green way for the addition of imines to avoid the need for metal reagents, chemical oxidants and reductants, which makes it has a good application prospect in drug synthesis.
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Zhang et al. (2025) studied this question.
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