Key result
The Åstrand-Rhyming prediction model validly estimated exercise capacity in breast cancer patients undergoing chemotherapy, showing a strong correlation and a small mean difference of 0.11 L/min compared to measured values.
Why the study?
Do the Ekblom-Bak test and Åstrand-Rhyming prediction model accurately predict measured VO2peak in patients with breast cancer undergoing chemotherapy?
Cross-Sectional (n=8)
Yes
Do the Ekblom-Bak test and Åstrand-Rhyming prediction model accurately predict measured VO2peak in patients with breast cancer undergoing chemotherapy?
The Åstrand-Rhyming prediction model provides a valid submaximal alternative for estimating cardiorespiratory fitness in breast cancer patients undergoing chemotherapy when maximal testing is not feasible.
Answers are grounded in this paper and cite their sources.
Oncology-specific VO2peak equations improve estimation accuracy in breast cancer; leaves open whether they should supplant direct CPET in routine care.
Background: Patients with breast cancer have an impaired cardiorespiratory fitness, in part, due to the toxic effects of anticancer therapy. Physical exercise as a means of rehabilitation for patients with cancer is an emerging area of research and treatment, emphasizing the need for accurate and feasible physical capacity measurements. The purpose of this study was to evaluate the validity of peak oxygen consumption ( JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak) predicted by the Ekblom-Bak test (E-B) and the Åstrand-Rhyming prediction model (A-R). Methods: Eight patients with breast cancer undergoing chemotherapy participated in the study. Submaximal exercise tests were performed at 2 different submaximal workloads. Estimated JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak values were obtained by inserting the heart rate (HR) from the 2 workloads into the E-B prediction model and the HR of only the higher workload into the Åstrand nomogram. A 20-W incremental cycle test-to-peak effort was performed to obtain JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak values. Results: Results from A-R overestimated JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak by 6% (coefficient of variation = 7%), whereas results from E-B overestimated JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak with 42% (coefficient of variation = 21%) compared with measured JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak. Pearson's correlation coefficient revealed a significant strong relationship between the estimated JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak from A-R and the measured JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak (r = 0.86; P < .05), whereas the relationship between the estimated JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak from E-B and the measured JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak resulted in a nonsignificant weak correlation (r = 0.21). Conclusion: In a situation where maximal exercise testing is not practical or undesirable from a patient safety perspective, submaximal exercise testing provides an alternative way of estimating JOURNAL/reonc/04.03/01893697-201610000-00004/4FSM1/v/2023-08-29T031421Z/r/image-gif o 2peak. The A-R prediction model appears to be a valid submaximal exercise test for determining cardiorespiratory fitness in this population.
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Mijwel et al. (2016) conducted a cross-sectional in Breast cancer undergoing chemotherapy (n=8). Åstrand-Rhyming prediction model vs. Measured VO2peak was evaluated on Difference between estimated VO2peak from A-R and measured VO2peak (MD 0.11 L/min, 95% CI -0.01 to 0.22). The Åstrand-Rhyming prediction model validly estimated exercise capacity in breast cancer patients undergoing chemotherapy, showing a strong correlation and a small mean difference of 0.11 L/min compared to measured values.
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