Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle

Xiao et al. (2016) studied Foot-and-mouth disease (FMDV serotype Asia1) (n=27). FMDV VLP subunit vaccine (serotype Asia1) vs. PBS (sham-vaccinated) was evaluated on 50% bovine protective dose (PD50) against FMDV challenge (11.75 PD50 per dose). A single dose of the E. coli-produced FMDV VLP subunit vaccine elicited strong protective immunity in cattle, achieving a high protection potency of 11.75 PD50 per dose against FMDV Asia1 challenge.