The Hemolytic-Uremic Syndrome Is a Syndrome

The article in this week's issue of the Journal by Koster and his colleagues raises important questions not only about the pathogenesis of the hemolytic-uremic syndrome but, perhaps more importantly, about the clinical conditions that can reasonably be included under this rubric.Since the description some 20 years ago by Gasser and his associates of a syndrome comprising acute hemolytic anemia, thrombocytopenia and renal insufficiency, ample evidence has been adduced from clinical, epidemiologic, histopathological and ultra-structural studies to permit the conclusion that this constellation of findings may occur in a number of distinctly different situations and in all likelihood is . . .