Key result
A staged hybrid approach for extensive aortic disease, utilizing TEVAR first followed by open repair, resulted in a 9% operative mortality rate after the open procedure and no late deaths.
Why the study?
Does a staged hybrid approach (TEVAR first followed by open repair) provide a safe and feasible treatment for patients with extensive aortic disease at high risk for conventional open repair?
Cohort (n=22)
Does a staged hybrid approach (TEVAR first followed by open repair) provide a safe and feasible treatment for patients with extensive aortic disease at high risk for conventional open repair?
A TEVAR-first staged hybrid approach is a feasible strategy for extensive aortic disease in high-risk patients, with a 9% operative mortality rate for the open completion stage.
Supports staged hybrid repair feasibility in extensive aortic disease; leaves open prospective validation before wider adoption.
OBJECTIVES: Repair of extensive aortic disease carries a significant risk of death and morbidity, the most feared complication being spinal cord ischaemia. Objectives of this study are to characterize patients, describe repair methods and assess feasibility and safety of hybrid staged repair for treatment of extensive aortic disease. METHODS: From to 2001 to 2013, 22 patients underwent extensive aortic repair that included a thoracic endovascular aortic repair (TEVAR) first followed by an open completion repair extending through the visceral and infrarenal aorta for degenerative aneurysm and dissection. At the time of initial repair, all patients were deemed to be at a high risk for conventional open repair and had extensive disease. Indications for open completion included emergency failure of TEVAR (n = 3), early two-stage approach (n = 6) and delayed disease progression after TEVAR (n = 13). The median interval between stages was 6.5 months. The mean age was 56 ± 14 years, 5 patients had connective tissue disorder and the mean maximum aortic diameter was 58 ± 16 mm preoperatively. RESULTS: There was no death or major complication after initial TEVAR, but the operative mortality rate was 9% (n = 2) after the open procedure. One of these patients died from intraoperative myocardial infarction during emergency repair, and the other had disseminated intravascular coagulation during delayed repair for disease progression after TEVAR. Other complications included paralysis in 1 (4.5%), tracheostomy in 2 (9%) and dialysis in 1 (4.5%), and there was 1 reoperation for bleeding (4.5%). The median follow-up was 37 (range 3.3-93) months and there were no late deaths. There were four late reoperations for proximal disease progression leading to Type 1 endoleak (n = 2), Type A dissection (n = 1) and root aneurysm (n = 1). CONCLUSIONS: Use of a TEVAR-first approach in combination with a staged open repair is a safe and feasible treatment strategy for repair of extensive aortic disease. A staged hybrid approach to aortic repair in patients at high risk for total aortic replacement may limit morbidity.
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Vivacqua et al. (2015) conducted a cohort in Extensive aortic disease (n=22). Staged hybrid approach (TEVAR first followed by open completion repair) was evaluated on Operative mortality after open procedure. A staged hybrid approach for extensive aortic disease, utilizing TEVAR first followed by open repair, resulted in a 9% operative mortality rate after the open procedure and no late deaths.
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