Key result
In pregnant women with prosthetic heart valves, low-dose warfarin with targeted parenteral heparin replacement during the first and late third trimesters optimizes maternal and fetal safety.
Population
Pregnant women with prosthetic heart valves (bioprosthetic or mechanical)
Design
Review
Authors
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May inform anticoagulation in pregnant patients with mechanical valves; leaves open need for prospective validation.
In pregnant women with mechanical heart valves, a regimen of low-dose warfarin with targeted parenteral heparin replacement during high-risk trimesters optimizes both maternal and fetal safety.
Pradhan et al. (2018) conducted a review in Prosthetic heart valves in pregnancy. Anticoagulation strategies for prosthetic heart valves was evaluated. In pregnant women with prosthetic heart valves, low-dose warfarin with targeted parenteral heparin replacement during the first and late third trimesters optimizes maternal and fetal safety.
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