Key result
Heart rate variability complexity, measured by the SD1 index, significantly increased in preterm infants after 45 days post-birth compared to within 15 days of birth (8.06 ms vs 1.28 ms, p=0.0007).
Why the study?
Premature infants may present with autonomic nervous system damage linked to poorer neurological development, prompting evaluation of heart rate variability across hospitalization times.
Does heart rate variability change over time in preterm infants during hospitalization?
Population
25 collections of preterm infants
Comparison
HRV within 15 days of birth vs after 45 days post-birth
Design
Longitudinal, prospective, and descriptive study
Follow-up
After 45 days post-birth
Authors
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HRV increases over hospitalization in preterm infants; leaves open whether serial monitoring predicts neurodevelopment or warrants clinical adoption.
Observational (n=25)
No
Does heart rate variability change over time in preterm infants during hospitalization?
Absolute Event Rate: 8.06% vs 1.28%
p-value: p=0.0007
Heart rate variability increases in premature infants over the first 45 days of life, indicating progressive maturation of the autonomic nervous system.
Filho et al. (2019) conducted an observational in Prematurity (n=25). Hospitalization time (after 45 days post-birth) vs. Within 15 days of birth was evaluated on Heart rate variability (SD1 index) (p=0.0007). Heart rate variability complexity, measured by the SD1 index, significantly increased in preterm infants after 45 days post-birth compared to within 15 days of birth (8.06 ms vs 1.28 ms, p=0.0007).
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