Key result
Older uterine cancer survivors who received adjuvant radiotherapy had a increased risk of developing peripheral arterial disease compared to matched normal controls.
Why the study?
The risk of peripheral arterial disease in long-term uterine cancer survivors remains unclear, particularly in Asian patients who are younger at diagnosis than Western counterparts.
What are the risk factors for developing peripheral arterial disease in long-term uterine cancer survivors compared to normal controls?
Cohort (n=9,445)
What are the risk factors for developing peripheral arterial disease in long-term uterine cancer survivors compared to normal controls?
Long-term uterine cancer survivors, particularly those with advanced age, hypertension, or receiving hormone replacement therapy, are at increased risk for peripheral arterial disease.
Answers are grounded in this paper and cite their sources.
May support PAD vigilance in UC survivors with hypertension or HRT; leaves open age-specific RT effects.
Background: The risk of peripheral arterial disease (PAD) in long-term uterine cancer (UC) survivors remains unclear, especially in Asian patients, who are younger at the diagnosis of UC than their Western counterparts. Methods: UC survivors, defined as those who survived for longer than 5 years after the diagnosis, were identified and matched at a 1:4 ratio with normal controls. Stratified Cox models were used to assess the risk of PAD. Results: From 2000 to 2005, 1,889 UC survivors who received surgery alone or surgery combined with radiotherapy (RT) were classified into young (onset age <50 years, n=894) and older (onset age ≥50 years, n=995) groups. While compared with normal controls, the young patients with diabetes, hypertension, and receiving hormone replacement therapy (HRT) were more likely to develop PAD. In contrast, the risk of PAD was associated with adjuvant RT, obesity, hypertension, and HRT in the older group. Among the UC survivors, those who were diagnosed at an advanced age (>65 years, aHR³2.48, P£0.011), had hypertension (aHR=2.18, P=0.008) or received HRT (aHR=3.52, P=0.020) were at higher risk of PAD. Conclusion: In this nationwide study, we found that the risk factors associated with PAD were similar in both cohorts except for adjuvant RT that was negligible in the young age group, but positive in the older group. Among the survivors, hypertension, advanced age, and HRT were more hazardous than RT. Secondary prevention should include PAD as a late complication in UC survivorship programs.
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Chen et al. (2021) conducted a cohort in Uterine cancer (n=9,445). Uterine cancer survivorship and adjuvant radiotherapy vs. Matched normal controls was evaluated on Development of peripheral arterial disease (PAD) in older uterine cancer survivors (≥50 years) receiving surgery and adjuvant radiotherapy compared to matched controls (aHR 2.12, 95% CI 1.13-3.95, p=0.019). Older uterine cancer survivors who received adjuvant radiotherapy had a increased risk of developing peripheral arterial disease compared to matched normal controls.
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