Key result
Hemodialysis patients had significantly lower aortic wall distensibility compared to normal controls (2.95 vs 6.61 x 10^-3 mmHg^-1, p<0.01), suggesting advanced aortic wall sclerosis.
Why the study?
Does aortic wall distensibility differ between hemodialysis patients and normal controls?
Case-Control (n=20)
Does aortic wall distensibility differ between hemodialysis patients and normal controls?
Hemodialysis patients exhibit significantly reduced aortic wall distensibility on cine MRI, suggesting advanced aortic wall sclerosis.
Answers are grounded in this paper and cite their sources.
May signal higher vascular risk in hemodialysis; leaves open whether distensibility predicts events or guides therapy.
To evaluate the aortic wall distensibility (AD) in hemodialysis patients, we measured AD at the ascending aorta using cine magnetic resonance imaging in 10 hemodialysis patients (HDP) and 10 normal controls (NC). Age and sex were matched in HDP and NC. Transverse image of the aorta was measured in the maximum and minimum frames. AD was calculated from the following formula: (Max. area — Min. area)/Min. area − pulse pressure). Although systolic blood pressure, diastolic blood pressure, and minimum area of ascending aorta showed no significant differences between HDP and NC, AD was significantly lower in HDP (2.95 ± 0.87 − 10 −3 mmHg −1 ) than in NC (6.61 ± 3.1 2× 10 −3 mmHg −1 ) ( p <0.01). It is suspected that hemodialysis patients have advanced aortic wall sclerosis.
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Matsumoto et al. (2005) conducted a case-control in Hemodialysis (n=20). Hemodialysis vs. Normal controls was evaluated on Aortic wall distensibility (AD) at the ascending aorta (p=<0.01). Hemodialysis patients had significantly lower aortic wall distensibility compared to normal controls (2.95 vs 6.61 x 10^-3 mmHg^-1, p<0.01), suggesting advanced aortic wall sclerosis.
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