Why the study?
Does essential hypertension reduce aortic distensibility measured by cine MRI compared to normal controls?
Does essential hypertension reduce aortic distensibility measured by cine MRI compared to normal controls?
Essential hypertension is associated with significantly reduced aortic distensibility across multiple aortic segments, suggesting it promotes aortic sclerosis.
Hypertension was associated with lower aortic distensibility on cine MRI; hypothesis-generating for stiffness as a modifiable marker, needs prospective validation.
In order to evaluate the exact distensibility in various parts of aorta in hypertensive patients, the authors performed cine magnetic resonance (MR) in 30 normal control (NC) subjects and 30 hypertensive (HT) patients whose age and sex were matched. Cine MR was carried out at transverse sections in the ascending, descending, and abdominal aorta. Aortic diameter and area were measured in the frames of the maximum and the minimum aortic area. Aortic distensibility was calculated from the following formula: (Max area-Min area)/(Min area x delta P), where delta P is pulse pressure. Cardiac parameters were measured with echocardiography in all subjects. Aortic distensibility was significantly lower in HT patients than in NC subjects at each transverse section (P < 0.01). Minimum diameter index (Min diameter/body surface area) and cardiac function parameter showed no significant differences between NC and HT groups. From these findings, it is suspected that hypertension is a strongly contributing factor that promotes aortic sclerosis.
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Honda et al. (1994) studied this question.
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