Key result
Phenylbutazone significantly potentiated the anticoagulant effect of warfarin in man, increasing prothrombin time and decreasing warfarin's plasma concentration and biologic half-life.
Why the study?
Does phenylbutazone potentiate the anticoagulant effect of warfarin in humans?
Does phenylbutazone potentiate the anticoagulant effect of warfarin in humans?
Phenylbutazone significantly potentiates the anticoagulant effect of warfarin, increasing prothrombin time while decreasing warfarin plasma concentration and half-life.
The anticoagulant effect of warfarin is significantly potentiated by phenylbutazone in man. Using a fluorometric assay method for warfarin that is not influenced by the presence of phenylbutazone the prothrombin time increased and the plasma concentration and biologic half-life of warfarin decreased during treatment with phenylbutazone. These results are in agreement with those obtained earlier by a spectrophotometric assay of warfarin in which a correction for interference of phenylbutazone had to be applied.
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O'Reilly et al. (1968) studied this question. Phenylbutazone was evaluated on Prothrombin time, plasma concentration, and biologic half-life of warfarin. Phenylbutazone significantly potentiated the anticoagulant effect of warfarin in man, increasing prothrombin time and decreasing warfarin's plasma concentration and biologic half-life.
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