Key result
A 60-year-old man presented with the first well-documented case of multicentric malignant fibrous histiocytoma arising from the stomach and small intestine.
Case Report (n=1)
This report documents what is believed to be the first case of malignant fibrous histiocytoma arising from the stomach and small intestine.
May prompt consideration of rare sarcomas in atypical GI masses; extends documented MFH sites but leaves open questions on incidence and therapy.
A case of multicentric malignant fibrous histiocytoma of the stomach and small intestine is reported. The patient was a 60-year-old man who had total gastrectomy under an impression of a gastric carcinoma. The resected stomach revealed a large polypoid mass in the antral portion at the greater curvature. Three months later, he developed ileus and an 80 cm segment of the jejunum was removed. It contained two polypoid masses identical to that seen in the stomach. The tumors showed, in addition to the characteristic light microscopic appearances, strong positivity for alpha-1-antitrypsin by an immunoperoxidase technique, indicating the diagnosis of malignant fibrous histiocytoma (MFH). Electron microscopic findings were also consistent with MFH. We believe that this is the first well-documented case of MFH arising from the stomach and small intestine, to the best of our knowledge.
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Shibuya et al. (1985) conducted a case report in Multicentric malignant fibrous histiocytoma of the stomach and small intestine (n=1). Total gastrectomy and jejunum resection was evaluated on Pathological diagnosis. A 60-year-old man presented with the first well-documented case of multicentric malignant fibrous histiocytoma arising from the stomach and small intestine.
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