Key result
Non-stenosing carotid atherosclerosis in patients with embolic stroke of undetermined source was significantly associated with increased arterial stiffness (OR 2.92).
Why the study?
Non-stenosing atherosclerosis and arterial stiffness may influence embolic stroke of undetermined source (ESUS), but their association was not defined.
Is non-stenosing carotid atherosclerosis associated with increased arterial stiffness in patients with embolic stroke of undetermined source?
Population
100 patients with ESUS and 48 patients with ischemic stroke from atherosclerosis
Comparison
Carotid non-stenosing atherosclerosis vs no non-stenosing atherosclerosis
Authors
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NSA associated with higher arterial stiffness in ESUS; hypothesis-generating for subtype risk profiles, needs prospective confirmation.
Cross-Sectional (n=148)
No
Is non-stenosing carotid atherosclerosis associated with increased arterial stiffness in patients with embolic stroke of undetermined source?
Odds Ratio: 2.92 (95% CI 1.18–7.56)
Absolute Event Rate: 52% vs 27%
p-value: p=0.012
ESUS patients with non-stenosing carotid atherosclerosis exhibit increased arterial stiffness and a cardiovascular risk profile similar to patients with atherosclerotic stroke.
Acampa et al. (2020) conducted a cross-sectional in Embolic Stroke of Undetermined Source (ESUS) (n=148). Non-stenosing carotid atherosclerosis vs. Absence of non-stenosing carotid atherosclerosis was evaluated on Arterial stiffness (ASI > 0.70) (OR 2.92, 95% CI 1.18-7.56, p=0.012). Non-stenosing carotid atherosclerosis in patients with embolic stroke of undetermined source was significantly associated with increased arterial stiffness (OR 2.92).
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