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Potential new tuberculosis treatment: Mefloquine (1), an antimalarial drug with simple, yet interesting structural features has been found to be active against Mycobacterium tuberculosis. Thus, this molecule is a good candidate as a lead compound in the search for new TB drugs. The design and synthesis of mefloquine analogues is described, and biological data against the TB organism are also presented.
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Jayaprakash et al. (2006) studied this question.
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