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Eleven strains of mice were injected intravenously with a single dose (0.2 mg) of DNP isogeneic IgG. Immediately thereafter, they were challenged intraperitoneally with the same dose of 0.2 mg DNP-KLH in complete Freund's adjuvant. The immune response of DNP was determined by the direct and indirect anti-DNP-PFC. Tolerance of DNP was induced in all strains of mice including the NZB, both in terms of direct and indirect PFC. No correlation was found between tolerance and immunity of a single antigenic determinant suggesting that these two immune phenomena might behave independently of each other.
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Borel et al. (1974) studied this question.
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