Preclinical study reveals that preimmunization with a thymus-independent conjugate blocks IgM-to-IgG class switching in mice, indicating selective paralysis of T-dependent precursors.
The shift from IgM anti-hapten antibody production to IgG anti-hapten antibody production, subsequent to challenge with a T-dependent conjugate, is inhibited in mice by preimmunization with the T-independent DNP-LE conjugate. The results suggest that DNP on levan triggers off 19A T-independent anti-hapten precursors and paralyzes 7S T-dependent anti-hapten precursors.
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Guercio et al. (1975) studied this question.
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