Key result
A standard CAPD regime of three 2-L daily exchanges yielded overall patient survival of 93%, 71%, and 57% at 1, 3, and 5 years, comparable to standard four 2-L exchange regimes.
Why the study?
Does a standard regime of three 2-L daily exchanges provide adequate survival and dialysis adequacy in CAPD patients?
Cohort (n=507)
No
Does a standard regime of three 2-L daily exchanges provide adequate survival and dialysis adequacy in CAPD patients?
A CAPD regimen of three 2-L daily exchanges achieves comparable age- and disease-adjusted survival to standard four 2-L exchange regimens, despite lower dialysis adequacy metrics.
Answers are grounded in this paper and cite their sources.
May support three-exchange CAPD consideration in select patients; leaves open adequacy and RCT confirmation.
Our objectives were to study long-term patient survival and dialysis adequacy of continuous ambulatory peritoneal dialysis (CAPD) patients treated with a standard regime of three 2-L daily exchanges. It was a retrospective analysis of patient survival and cross-sectional analysis of adequacy of dialysis. The setting was a dialysis unit in a tertiary referral center of a teaching hospital. All patients (n = 507) accepted into the CAPD program from 1983 to June 1994, were analyzed for survival. Adequacy of dialysis was analyzed in all existing patients in 1993 to 1994. The overall patient survival was 93%, 71%, and 57% at one, three, and five years, respectively. The three-year survival rate was 40% for diabetics and 78% for nondiabetics. It was 86%, 85%, 64%, and 43% for patients aged <35, 35 -50, 50 -65, and over 65 years, respectively. The mean weekly KT/V of 201 existing CAPD patients was 1.76, and creatinine clearance was 57 Uweek/1.73 m2. KT/V by dialysis was only 1.57. The ageand disease-adjusted survival in our center was comparable to centers that used standard four 2-L exchange regimes, despite a substantially lower mean KT/V and creatinine clearance (CrCI).
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Lo et al. (1996) conducted a cohort in Continuous ambulatory peritoneal dialysis (CAPD) (n=507). Three 2-L daily exchanges vs. Standard four 2-L exchange regimes was evaluated on Overall patient survival at 5 years. A standard CAPD regime of three 2-L daily exchanges yielded overall patient survival of 93%, 71%, and 57% at 1, 3, and 5 years, comparable to standard four 2-L exchange regimes.
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