Key result
The FVII 10976G/A polymorphism was significantly associated with deep venous thromboembolism (P<0.05), whereas ACE, GPIa, t-PA, and TFPI polymorphisms showed no association.
Why the study?
Are specific thrombophilic gene polymorphisms associated with an increased risk of deep venous thromboembolism?
Case-Control (n=693)
Are specific thrombophilic gene polymorphisms associated with an increased risk of deep venous thromboembolism?
p-value: p=<0.05
The FVII 10976G/A polymorphism is significantly associated with a genetic predisposition to deep venous thromboembolism.
FVII 10976G/A may confer DVT susceptibility; hypothesis-generating and requires replication before informing clinical testing.
Recently much attention has been paid to the possibly considerable role of the thrombophilic gene polymorphisms in the pathogenesis of deep venous thromboembolism (DVT). However, the reported results are controversial. Hence, this study aimed to disclose the association between factor VII (FVII) 10976G/A, angiotensin-converting enzyme (ACE; intron 16 I/D), glycoprotein Ia (GPIa) 807C/T, tissue-type plasminogen activator (t-PA; intron 8 D/I) and tissue-factor pathway inhibitor 536C/T polymorphisms and DVT. We investigated these gene polymorphisms in 693 study participants including 193 patients who showed clinical symptoms of DVT and 500 healthy individuals without both personal and family histories of thromboembolic disorders. Genotyping was performed using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique. Comparison of genotypes distribution revealed that the FVII 10976G/A polymorphism was significantly related with DVT (P < 0.05), whereas there was no association between the ACE (intron 16 I/D), GPIa807C/T, t-PA (intron 8 D/I) and tissue-factor pathway inhibitor 536C/T gene polymorphisms and DVT (P > 0.05). In addition, the prevalence of homozygote genotype and mutant allele for FVII 10976G/A polymorphism was significantly higher in cases compared with controls (P < 0.05). Taken together, our data provide evidence to support the hypothesis that FVII 10976G/A polymorphism may be associated with a predisposition to DVT.
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Bargahi et al. (2016) conducted a case-control in Deep venous thromboembolism (DVT) (n=693). Thrombophilic gene polymorphisms (FVII 10976G/A, ACE, GPIa, t-PA, TFPI) vs. Healthy controls was evaluated on Association with deep venous thromboembolism (p=<0.05). The FVII 10976G/A polymorphism was significantly associated with deep venous thromboembolism (P<0.05), whereas ACE, GPIa, t-PA, and TFPI polymorphisms showed no association.
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