Key result
Amiodarone infusion in rabbit lungs caused acute edema (5.7 g/min), which was significantly attenuated by hypoxia or antioxidants like BHA (0.05 g/min, P<0.01), suggesting an oxidant mechanism.
Why the study?
Does amiodarone cause acute oxidant lung injury in ventilated and perfused rabbit lungs?
Population
Ventilated and perfused rabbit lungs
Comparison
Amiodarone infused into the inflow circuit vs Baseline, or amiodarone combined with protective…
Design
Preclinical
Follow-up
Immediate/acute
Authors
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Hypothesis-generating for oxidant-mediated amiodarone lung injury; clinical relevance and antioxidant protection require human validation.
Does amiodarone cause acute oxidant lung injury in ventilated and perfused rabbit lungs?
p-value: p=<0.01
Amiodarone induces acute lung injury in a rabbit model via an oxidant-mediated mechanism, which can be attenuated by antioxidant therapies.
Kennedy et al. (1988) studied Amiodarone-induced lung injury. Amiodarone vs. Hypoxia (4% O2) or antioxidant pretreatments (BHA, Vitamin E, N-acetylcysteine) was evaluated on Lung weight gain from baseline (delta W) (p=<0.01). Amiodarone infusion in rabbit lungs caused acute edema (5.7 g/min), which was significantly attenuated by hypoxia or antioxidants like BHA (0.05 g/min, P<0.01), suggesting an oxidant mechanism.
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