Key result
Amiodarone administration in rats caused dose-dependent increases in tissue drug levels and ultrastructural changes, including lamellar inclusion bodies in alveolar macrophages and liver.
Authors
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Amiodarone rat findings should not change clinical monitoring; leaves open translation of dose-dependent phospholipidosis to humans.
Kannan et al. (1989) studied this question. Amiodarone vs. Saline controls was evaluated on Accumulation of amiodarone and desethylamiodarone in lung and liver, and ultrastructural changes. Amiodarone administration in rats caused dose-dependent increases in tissue drug levels and ultrastructural changes, including lamellar inclusion bodies in alveolar macrophages and liver.
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