Population
Fischer-344 rats
Design
Preclinical
Follow-up
up to 9 weeks
Authors
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Offers reversible rat model of amiodarone phospholipidosis; leaves open human translation and dosing relevance.
Amiodarone and its major metabolite desethylamiodarone induce a dose- and time-dependent, reversible phospholipidosis in rat alveolar macrophages, providing a model for amiodarone pulmonary toxicity.
Reasor et al. (1988) studied this question.
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