Population
Fisher-344 male rats (200 to 250 g)
Comparison
Amiodarone or desethylamiodarone 100 mg/kg/d… vs Pair-fed control rats
Design
Preclinical
Follow-up
Up to 21 days
Authors
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DEA's higher mortality despite equivalent phospholipidosis challenges it as sole toxicity driver; hypothesis-generating in rats, no clinical implications yet.
Amiodarone and its metabolite DEA induce pulmonary phospholipidosis in rats via selective in vivo inhibition of phospholipases, with DEA exhibiting significantly higher mortality.
Kodavanti et al. (1991) studied this question.
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