Population
Male Fischer 344 rats
Design
Preclinical
Follow-up
Up to 9 weeks
Authors
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May implicate macrophages in amiodarone pulmonary toxicity; leaves open human relevance and therapeutic targeting.
Alveolar macrophages play a critical role in the sequestration of amiodarone and its metabolites in the lung, providing mechanistic insight into amiodarone-induced pulmonary toxicity.
Reasor et al. (1990) studied this question.
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