Key result
Amiodarone in rats increases spleen malondialdehyde ~30% via phospholipidosis without directly increasing oxidative stress.
Why the study?
Does amiodarone induce toxicity via oxidative stress in Fischer-344 rats?
Population
40 Fischer-344 rats
Comparison
Amiodarone 60 mg/kg/day injected for 21 days vs Saline injections for 21 days
Design
Preclinical
Follow-up
21 days
Authors
Loading...
Amiodarone toxicity not directly mediated by oxidative stress in rats; hypothesis-generating for mechanisms and human relevance.
Does amiodarone induce toxicity via oxidative stress in Fischer-344 rats?
Absolute Event Rate: 23.7% vs 18.2%
p-value: p=<.0001
Amiodarone-induced pulmonary and hepatic toxicity does not appear to be directly mediated by oxidative stress in a chronic rat model.
Sarma et al. (1997) studied Amiodarone-induced toxicity (n=40). Amiodarone vs. Saline injections was evaluated on Spleen malondialdehyde levels (µM/g tissue) (p=<.0001). Amiodarone treatment in rats did not directly increase oxidative stress, but increased spleen malondialdehyde levels (23.7 vs 18.2 µM/g tissue, P<.0001) secondary to phospholipidosis.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: