Why the study?
Does antioxidant therapy prevent amiodarone-induced free radical toxicity in rat models?
Population
Rats (in vivo) and in vitro models (liver homogenate, liver microsomal fraction)
Comparison
Amiodarone alone or together with antioxidants… vs Amiodarone alone or antioxidant alone
Design
Preclinical
Follow-up
30 days
Authors
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Silibinin may attenuate amiodarone-induced lysosomal changes in rat lung; hypothesis-generating and should not yet inform clinical practice.
Does antioxidant therapy prevent amiodarone-induced free radical toxicity in rat models?
Amiodarone toxicity may be partially mediated by free radical generation, and antioxidants like silibinin offer partial protection against cellular damage in rat models.
Vereckei et al. (1993) studied this question.
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