Why the study?
Does amiodarone induce acute renal damage in male Wistar rats?
Population
13 male Wistar rats
Comparison
Amiodarone 50 mg/kg body weight daily… vs Control group
Design
Preclinical
Follow-up
6 days
Authors
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Amiodarone may induce renal injury in rats; hypothesis-generating for human nephrotoxicity and should not change practice.
Does amiodarone induce acute renal damage in male Wistar rats?
Amiodarone administration in a rat model induces acute renal damage, highlighting a potential nephrotoxic side effect of this antiarrhythmic drug.
Morales et al. (2003) studied this question.
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