Key result
A physiologically based model of insulin dynamics provided a useful description of insulin disposition and allowed for the assessment of muscle insulin uptake in 154 women.
A novel physiologically based model successfully describes insulin disposition and allows for the assessment of muscle insulin uptake in women without requiring C-peptide data.
New physiologically based insulin model profiles endogenous secretion without C-peptide; leaves open validation before clinical or research adoption.
Currently available models of insulin dynamics are mostly based on the classical compartmental structure and, thus, their physiological utility is limited. In this work, we describe the development of a physiologically based model and its application to data from 154 patients who underwent an insulin-modified intravenous glucose tolerance test (IM-IVGTT). To determine the time profile of endogenous insulin delivery without using C-peptide data and to evaluate the transcapillary transport of insulin, the hepatosplanchnic, renal, and peripheral beds were incorporated into the circulatory model as separate subsystems. Physiologically reasonable population mean estimates were obtained for all estimated model parameters, including plasma volume, interstitial volume of the peripheral circulation (mainly skeletal muscle), uptake clearance into the interstitial space, hepatic and renal clearance, as well as total insulin delivery into plasma. The results indicate that, at a population level, the proposed physiologically based model provides a useful description of insulin disposition, which allows for the assessment of muscle insulin uptake.
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Weiß et al. (2015) studied this question. Physiologically based model of insulin dynamics was evaluated on Model parameters including plasma volume, interstitial volume, uptake clearance, hepatic and renal clearance, and total insulin delivery. A physiologically based model of insulin dynamics provided a useful description of insulin disposition and allowed for the assessment of muscle insulin uptake in 154 women.
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