Key result
Cigarette smoking was associated with a 24% decrease in mean platelet NADH CoQ1 reductase (complex I) activity compared to non-smoking controls (p < 0.02).
Why the study?
Does cigarette smoking alter mitochondrial respiratory chain enzyme activities in platelets of healthy individuals?
Population
41 normal healthy individuals (18 non-smoking controls, 23 cigarette smoking individuals)
Comparison
Cigarette smoking vs Non-smoking
Design
Cross-sectional
Authors
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No immediate practice implications for smokers; leaves open whether platelet complex I inhibition contributes to cardiovascular risk.
Observational (n=41)
Does cigarette smoking alter mitochondrial respiratory chain enzyme activities in platelets of healthy individuals?
Effect estimate: 24% decrease
p-value: p=<0.02
Cigarette smoking is associated with a significant decrease in platelet mitochondrial complex I activity, demonstrating in vivo mitochondrial inhibition by an environmental agent.
Smith et al. (1993) conducted an observational in Healthy individuals (n=41). Cigarette smoking vs. Non-smoking was evaluated on Mean NADH CoQ1 reductase (complex I) activity (24% decrease, p=<0.02). Cigarette smoking was associated with a 24% decrease in mean platelet NADH CoQ1 reductase (complex I) activity compared to non-smoking controls (p < 0.02).
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