Key result
Early coronary angiography in patients with out-of-hospital cardiac arrest without ST-elevation does not improve survival or chance of good neurological outcome compared to delayed angiography.
Why the study?
Less than 40% of patients with out-of-hospital cardiac arrest with return of spontaneous circulation survive to discharge.
Does early coronary angiography improve survival or neurological outcome in patients with out-of-hospital cardiac arrest without ST-segment elevation compared to delayed angiography?
Meta-Analysis (n=1,590)
Yes
Does early coronary angiography improve survival or neurological outcome in patients with out-of-hospital cardiac arrest without ST-segment elevation compared to delayed angiography?
Early coronary angiography does not provide survival or neurological benefits over delayed angiography in patients with out-of-hospital cardiac arrest without ST-segment elevation.
Answers are grounded in this paper and cite their sources.
Supports delayed angiography in OHCA without ST-elevation; confirms no survival or neurological benefit in meta-analysis.
Red (no benefits) Summary heading Early angiography in patients with OHCA without ST-elevation does not improve survival or chance of good neurological outcome Benefits in NNT No one was helped (no death prevented) No one was helped (good neurological outcome) Benefits in percentages No one was helped Harms in NNT (NNH) Similar risk of harm between early and delayed intervention Harms in percentages Similar risk of harm between early and delayed intervention Efficacy endpoints Mortality, good neurological function Harm endpoints Adverse events such as ventricular arrhythmias, major bleeding, and acute kidney injury Who was in the studies 1590 patients with OCHA randomized to early coronary angiography or delayed angiography enrolled in six randomized controlled trials NARR ATIVELess than 40% of patients with out-of-hospital cardiac arrest (OHCA)with return of spontaneous circulation (ROSC) survive to discharge.
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Davila et al. (2023) conducted a meta-analysis in Out-of-hospital cardiac arrest (OHCA) without ST-segment elevation (n=1,590). Early coronary angiography vs. Delayed angiography was evaluated on Mortality and good neurological function. Early coronary angiography in patients with out-of-hospital cardiac arrest without ST-elevation does not improve survival or chance of good neurological outcome compared to delayed angiography.
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