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N, 2-substituted buta-2,3-dienoates reacted with oxime chlorides to afford spirobiisoxazolines in 55-90% yields via the double 1,3-dipolar cycloaddition. Notably, the construction of double isoxazoline moieties and two chiral centers including a spiro carbon center was achieved.
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Shang et al. (2018) studied this question.
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