Key result
Percutaneous mitral valve repair significantly decreased P wave duration, P wave amplitude, and PR interval (P < .05) in patients with sinus rhythm, with no changes in QRS or QT intervals.
Why the study?
Mitral regurgitation induces left atrial remodeling that alters excitability and conduction, but electroanatomical changes after percutaneous mitral valve repair had not been studied.
Does percutaneous mitral valve repair (PMVR) alter surface ECG parameters in patients with mitral regurgitation in sinus rhythm?
Observational (n=104)
Does percutaneous mitral valve repair (PMVR) alter surface ECG parameters in patients with mitral regurgitation in sinus rhythm?
Percutaneous mitral valve repair leads to significant decreases in P wave duration, amplitude, and PR interval, suggesting favorable reverse electrical remodeling of the atrium.
PMVR-associated atrial mapping changes may signal arrhythmia risk; leaves open whether remodeling reversal alters AF incidence in high-risk patients.
BACKGROUND: Mitral regurgitation (MR) has a severe impact on hemodynamics and induces severe structural changes in the left atrium. Atrial remodeling is known to alter excitability and conduction in the atrium facilitating atrial fibrillation and atrial flutter. PMVR is a feasible and highly effective procedure to reduce MR in high-risk patients, which are likely to suffer from atrial rhythm disturbances. So far, electroanatomical changes after PMVR have not been studied. HYPOTHESIS: In the current study, we investigated changes in surface electrocardiograms (ECGs) of patients undergoing PMVR for reduction of MR. METHODS: We evaluated 104 surface ECGs from patients in sinus rhythm undergoing PMVR. P wave duration, P wave amplitude, PR interval, QRS duration, QRS axis, and QT interval were evaluated before and after PMVR and at follow-up. RESULTS: We found no changes in QRS duration, QRS axis, and QT interval after successful PMVR. However, P wave duration, amplitude, and PR interval were significantly decreased after reduction of MR through PMVR (P < .05, respectively). CONCLUSION: The data we provide offers insight into changes in atrial conduction after reduction of MR using PMVR in patients with sinus rhythm.
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Hou et al. (2019) conducted an observational in Mitral regurgitation (n=104). Percutaneous edge-to-edge mitral valve repair (PMVR) vs. Baseline (before PMVR) was evaluated on Changes in surface electrocardiogram parameters (P wave duration, P wave amplitude, PR interval, QRS duration, QRS axis, and QT interval) (p=<.05). Percutaneous mitral valve repair significantly decreased P wave duration, P wave amplitude, and PR interval (P < .05) in patients with sinus rhythm, with no changes in QRS or QT intervals.
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