Key result
Premature ovarian insufficiency was associated with significantly decreased native and total thiol levels and increased carotid intima-media thickness (P<0.001) compared to healthy controls.
Why the study?
The relationship between oxidative stress, assessed via dynamic thiol/disulfide homeostasis parameters, and subclinical atherosclerosis measured by carotid intima-media thickness in patients with premature ovarian insufficiency was unclear.
Is premature ovarian insufficiency associated with increased oxidative stress and subclinical atherosclerosis compared to healthy controls?
Cross-Sectional (n=69)
Is premature ovarian insufficiency associated with increased oxidative stress and subclinical atherosclerosis compared to healthy controls?
Premature ovarian insufficiency is associated with increased carotid intima-media thickness and decreased antioxidant thiol levels, suggesting oxidative stress contributes to subclinical atherosclerosis in these patients.
Objective: We aimed to investigate the relationship between oxidative stress (OS) and subclinical atherosclerosis in patients with premature ovarian insufficiency (POI), by analyzing the dynamic thiol/disulfide homeostasis (TDH) parameters as an OS marker and carotid intima-media thickness (CIMT).Materials and methods: A total of 69 women, 34 with POI and 35 healthy controls were included in this prospective cross-sectional study. TDH parameters (plasma native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios) and CIMT were measured and compared between the two groups.Results: In primary ovarian insufficiency group, native thiol (p=.009) and total thiol (p=.010) levels were significantly decreased, and CIMT values were significantly increased (p= <.001). CIMT values were negatively correlated with native thiol (r=–0.553, p=.001) and total thiol levels (r=–0.565, p=.001); and positively correlated with age (r = 0.457, p=.007), BMI (r = 0.408, p=.017), and total cholesterol (r = 0.605, p<.001) in POI group.Conclusions: Decreased native thiol and total thiol levels demonstrate the defective anti-oxidant mechanism in POI. Negative correlation between native thiol, total thiol levels, and CIMT means the presence of abnormal anti-oxidant mechanisms may play a role in the development of subclinical atherosclerosis in patients with POI. This is a novel report on the mechanism of subclinical atherosclerosis in women with POI, which needs to be supported with further studies evaluating the pathophysiology of OS.
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Bozkaya et al. (2020) conducted a cross-sectional in Premature ovarian insufficiency (POI) (n=69). Premature ovarian insufficiency vs. Healthy controls was evaluated on Thiol/disulfide homeostasis parameters and carotid intima-media thickness (CIMT) (p=<0.001). Premature ovarian insufficiency was associated with significantly decreased native and total thiol levels and increased carotid intima-media thickness (P<0.001) compared to healthy controls.
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