The cardiovascular risk profile of middle age women previously diagnosed with premature ovarian insufficiency: A case-control study

March 5, 2020PLoS ONEOpen Access

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Key Points

To evaluate the cardiovascular risk profile of middle-aged women previously diagnosed with premature ovarian insufficiency compared to matched controls.
Compared 123 women with POI to 123 controls matched for age and BMI.
Assessed cardiovascular risk factors including waist circumference, blood pressure, and metabolic syndrome.
Calculated 10-year Framingham Risk Score and cardiovascular health score for both groups.
Women with POI had significantly higher waist circumference and prevalence of hypertension compared to controls (p<0.01).
No significant differences in arterial stiffness (PWV) or glucose levels between groups (p=0.21).
Carotid intima media thickness was lower in women with POI (550 μm vs. 684 μm, p<0.01).

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Case-control study compares cardiovascular risk in women with premature ovarian insufficiency and matched controls, suggesting specific risk factors.

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Gunning et al. (2020) studied this question.

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