Amides were synthesized from carboxylic acids and isocyanides under PdII/AgI/base catalytic conditions. The reaction conditions were optimized, and the scope was studied. Various carboxylic acids and aryl isocyanides are compatible with this reaction, but alkyl isocyanides are not. A plausible mechanism, which features distinctive PdII‐mediated decarbonylative coupling and unprecedented nucleophilic attack of carboxylates to PdII‐ligated isocyanides, was proposed to account for this reaction.
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Huang et al. (2013) studied this question.
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