Key result
Higher parathyroid hormone levels were independently associated with a high Wilkins score (≥7) in patients with rheumatic mitral valve disease (OR 1.017).
Why the study?
Rheumatic mitral valve disease is linked to autoimmune valve injury, and PTH and vitamin D affect the immune system, but their relationship in these patients is unclear.
Are parathyroid hormone and vitamin D levels associated with rheumatic mitral valve disease and its echocardiographic severity?
Cross-Sectional (n=156)
Are parathyroid hormone and vitamin D levels associated with rheumatic mitral valve disease and its echocardiographic severity?
Vitamin D levels are lower in RMVD patients, and higher PTH levels independently predict a higher Wilkins score, suggesting a role for calcium metabolism in rheumatic valve damage.
Answers are grounded in this paper and cite their sources.
Does not support PTH testing in RMVD; leaves open calcium metabolism's role in valve severity.
Introduction: Rheumatic mitral valve disease (RMVD) is associated with autoimmune heart valve injury. Parathyroid hormone (PTH) and vitamin D are two essential molecules that have effects on the immune system. In this study, we aimed to evaluate the relationship between PTH and vitamin D in patients with RMVD. Patients and Methods: We investigated 81 patients with RMVD and 75 healthy subjects. According to Wilkins score, baseline clinical, laboratory, and echocardiographic parameters were recorded, and all RMVD patients were analyzed. Multivariate logistic regression analysis was performed between the groups. Results: Vitamin D levels were significantly low in the RMVD group. Patients were stratified according to Wilkins score [Wilkins score<7 (n= 50) vs. Wilkins score ≥7 (n= 31)]. Age, BMI, and PTH were significantly higher, and mitral valve area was significantly lower in Wilkins score ≥7 patients. In multivariate analysis, age (OR= 1.052; 95% CI 1.005-1.100, p= 0.028) and PTH (OR= 1.017; 95% CI 1.000-1.033, p= 0.047) were found to be independent predictors of high Wilkins score. Conclusion: This study showed that vitamin D levels were low in patients with RMVD. According to the Wilkins score, PTH levels were significantly high in patients with a high Wilkins score. Changes in PTH and vitamin D levels may trigger inflammation and be responsible for valve damage.
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Çelik et al. (2021) conducted a cross-sectional in Rheumatic mitral valve disease (n=156). Parathyroid hormone (PTH) levels was evaluated on High Wilkins score (≥7) (OR 1.017, 95% CI 1.000-1.033, p=0.047). Higher parathyroid hormone levels were independently associated with a high Wilkins score (≥7) in patients with rheumatic mitral valve disease (OR 1.017).
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