Key result
Chronic heart valve disease was associated with higher PTH, increased oxidative stress, and calcidiol deficiency, with calcidiol negatively correlating with the oxidative stress index.
Why the study?
Are calcidiol deficiency, elevated PTH, and oxidative stress associated with mitral and aortic valve insufficiency compared to healthy controls?
Case-Control (n=96)
Are calcidiol deficiency, elevated PTH, and oxidative stress associated with mitral and aortic valve insufficiency compared to healthy controls?
Vitamin D deficiency, elevated PTH, and increased oxidative stress are highly prevalent and correlated in patients with chronic mitral and aortic valve regurgitation.
Answers are grounded in this paper and cite their sources.
Should not yet change practice in valvular disease; leaves open mechanistic and therapeutic roles for calcidiol and PTH.
OBJECTIVES: Endothelia, intima, and connective tissues comprise the heart valves, but the relationship between heart valve damage, the pathogenesis of valve degeneration, and vitamin D, oxidative stress remains unclear. Here, we assessed serum 25(OH) vitamin D (calcidiol), parathormone (PTH), and redox balance in patients with mitral valve regurgitation (MR) and aortic valve regurgitation (AR). METHODS: This study includes 56 chronic heart valve disease (HVD) patients. Patients were diagnosed with MR or AR depending on the echocardiographic findings. Also, 40 sex-matched healthy control participants were enrolled for comparison. Serum calcidiol, PTH, total oxidative status (TOS), and total antioxidative capacity were measured, and the oxidative stress index (OSI) was calculated. RESULTS: Patients with HVD demonstrated significantly higher PTH, increased TOS and OSI, and a higher frequency of calcidiol deficiency than the control participants. Calcidiol and TOS were negatively correlated (r = -0.29; P <0.005), as were calcidiol and OSI (r = -0.413; P = 0.001). PTH and OSI were positively correlated (r = 0.22; P = 0.02). DISCUSSION: We demonstrate that vitamin D deficiency and secondary increases in PTH are highly prevalent. Heart valve regurgitation (AR and MR) is correlated to oxidative stress and hypovitaminosis D.
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Eren et al. (2013) conducted a case-control in Chronic heart valve disease (mitral and aortic valve insufficiency) (n=96). Chronic heart valve disease vs. Healthy controls was evaluated on Serum calcidiol, parathormone (PTH), total oxidative status (TOS), and oxidative stress index (OSI). Chronic heart valve disease was associated with higher PTH, increased oxidative stress, and calcidiol deficiency, with calcidiol negatively correlating with the oxidative stress index.
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