Key result
Severe valvular heart disease is linked to higher oxidative stress, directly correlating with elevated cardiac biomarkers.
Why the study?
Oxidative stress is a key causative factor in heart disease, but its role and relationship to valvular heart disease risk markers in humans needed illumination.
Does dysregulated oxidative stress correlate with cardiac biomarkers (CRP, hs-cTnI, hs-cTnT) in patients with severe valvular heart disease compared to healthy individuals?
Case-Control (n=253)
No
Does dysregulated oxidative stress correlate with cardiac biomarkers (CRP, hs-cTnI, hs-cTnT) in patients with severe valvular heart disease compared to healthy individuals?
Oxidative stress is elevated in severe valvular heart disease and positively correlates with markers of inflammation and myocardial damage.
Answers are grounded in this paper and cite their sources.
Oxidative stress links to inflammation and troponin rise in severe VHD; hypothesis-generating, should not yet change practice.
Background: Valvular heart disease (VHD) is a major contributor to loss of physical function and longevity. Oxidative stress is one of the key causative factors involved in heart disease including VHD. Here, we aimed to illuminate the role and relation of oxidative stress to the VHD risk markers in the human population. Materials and Methods: 150 VHD patients and 103 healthy individuals as control were selected for the study and were divided into three groups: the aortic valve, mitral valve, and combined disease based on valvular calcification. Results: Our results demonstrated enhanced oxidative stress in the VHD condition, as we found elevated levels of reactive oxygen species (ROS) at the serum, supported by an increased level of thiobarbituric acid reactive substances (TBARs) in the cardiac valvular tissues of the VHD patients. In contrast, we experienced declined antioxidants including Super Oxide Dismutase (SOD), catalase (CAT), and peroxidase (POD) activities. Concurrently, increasing levels of C-reactive protein (CRP), high-sensitivity cardiac troponin I (hs-cTnI), and high-sensitivity cardiac troponin T (hs-cTnT) were detected in the aortic, mitral, and combined disease condition, suggesting a key association of oxidative stress to VHD conditions. Furthermore, regression analysis validated a key association between the impairment of the redox system (ROS and antioxidant enzyme activities) and VHD condition. Conclusion: Taken together, dysregulated oxidative stress contributes to the progression of VHD via positively correlating with CRP, hs-TnI, and hs-TnT level.
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Jan et al. (2022) conducted a case-control in Valvular heart disease (n=253). Severe valvular heart disease vs. Healthy individuals was evaluated on Correlation between oxidative stress (ROS) and VHD risk markers (CRP, hs-cTnI, hs-cTnT). Patients with severe valvular heart disease exhibited enhanced oxidative stress and elevated levels of CRP, hs-cTnI, and hs-cTnT, which positively correlated with reactive oxygen species.
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