March 4, 2023CellsOpen Access

Relationship between Oxidative Stress and Left Ventricle Markers in Patients with Chronic Heart Failure

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Why the study?

Oxidative stress is implicated in CHF development, but whether serum oxidative stress markers differ based on left ventricular geometry and function was unclear.

Comparison

HFrEF vs HFpEF and four LV geometry groups

Design

Observational cross-sectional study

Authors

AMAušra MongirdienėLithuanian University of Health Sciences ALAgnė LiuizėLithuanian University of Health Sciences DKDovilė KarčiauskaitėVilnius University

Discussion

Member takes

Implication

Oxidative stress markers may correlate with LV parameters across HF phenotypes; leaves open targeted interventions pending prospective trials.

Structured PICO

Population

60 patients with chronic heart failure (CHF), stratified by LVEF into HFrEF (<40%, n=27) and HFpEF (≥40%, n=33), and by LV geometry into normal (n=7), concentric remodeling (n=14), concentric LV hypertrophy (n=16), and eccentric LV hypertrophy (n=23).

Outcome

Differences in serum oxidative (NT-Tyr, dityrosine, PC, MDA, oxHDL) and antioxidative (TAC, catalase) stress markers according to LVEF and LV geometrysurrogate

Serum oxidative and antioxidative stress markers do not significantly differ based on left ventricular ejection fraction or geometry in patients with chronic heart failure.

Cite This Study

Mongirdienė et al. (2023) studied this question.

synapsesocial.com/papers/6a70c7ba6c240de38cdbeeac https://doi.org/10.3390/cells12050803

Topics

HFrEF treatment Heart failure

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Implication

Oxidative stress markers may correlate with LV parameters across HF phenotypes; leaves open targeted interventions pending prospective trials.

Relationship between Oxidative Stress and Left Ventricle Markers in Patients with Chronic Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Relationship between Oxidative Stress and Left Ventricle Markers in Patients with Chronic Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider