Serum Oxidative Stress Level Correlates with Clinical Parameters in Chronic Systolic Heart Failure Patients
Key result
Higher oxidative stress in HFrEF is linked to worse NYHA class, renal function, and elevated NT-proBNP.
- P<.001
- n=82
Why the study?
Does serum oxidative stress level correlate with clinical and prognostic parameters in patients with chronic systolic heart failure?
Population
82 consecutive chronic symptomatic heart failure patients with systolic LV dysfunction
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Higher OS levels associate with advanced HF and prognostic markers; hypothesis-generating for risk stratification, should not yet change practice.
Study Design
Type
Observational (n=82)
Structured PICO
Does serum oxidative stress level correlate with clinical and prognostic parameters in patients with chronic systolic heart failure?
P
Population
82 consecutive chronic symptomatic heart failure patients with systolic left ventricular dysfunction (ejection fraction <45%).
O
Outcome
Correlation of serum oxidative stress levels with clinical and prognostic parameters (NYHA class, renal function, hs-CRP, NT-proBNP)surrogate
Main Result
p-value: p=<.001
In patients with chronic systolic heart failure, elevated serum oxidative stress levels correlate with advanced disease severity and established markers of poor prognosis.
Cite This Study
Amir et al. (2009) conducted an observational in Chronic systolic heart failure (n=82). Serum oxidative stress levels was evaluated on Association with clinical and prognostic parameters (NYHA class, renal function, hs-CRP, NT-proBNP) (p=<.001). Higher serum oxidative stress levels in chronic systolic heart failure patients were associated with higher NYHA class (P=0.01), worse renal function (P<0.001), and higher NT-proBNP (P<0.001).