Key result
Essential hypertension linked to reduced GLS and higher LVEDP correlating with increased oxidative stress.
Why the study?
Is oxidative stress associated with alterations in left ventricular mechanics in patients with essential hypertension?
Case-Control (n=50)
Is oxidative stress associated with alterations in left ventricular mechanics in patients with essential hypertension?
Absolute Event Rate: -12% vs -16%
p-value: p=<0.05
Increased oxidative stress in essential hypertension is significantly correlated with subclinical left ventricular mechanical dysfunction, as evidenced by impaired global longitudinal strain and elevated end-diastolic pressure.
Oxidative stress may associate with impaired GLS and higher LVEDP in hypertension; leaves open causal links and therapeutic targets.
The oxidative stress state is characterized by an increase in oxygen reactive species that overwhelms the antioxidant defense; we do not know if these pathological changes are correlated with alterations in left ventricular mechanics. The aim was correlating the oxidative stress state with the left ventricular global longitudinal strain (GLS) and the left ventricular end diastolic pressure (LVEDP). Twenty-five patients with essential hypertension and 25 controls paired by age and gender were studied. All of the participants were subjected to echocardiography and biochemical determination of oxidative stress markers. The hypertensive patients, compared with control subjects, had significantly (p < 0.05) higher levels of oxidized proteins (5.03 ± 1.05 versus 4.06 ± 0.63 nmol/mg), lower levels of extracellular superoxide dismutase (EC-SOD) activity (0.045 ± 0.02 versus 0.082 ± 0.02 U/mg), higher LVEDP (16.2 ± 4.5 versus 11.3 ± 1.6 mm Hg), and lower GLS (-12% versus -16%). Both groups had preserved ejection fraction and the results showed a positive correlation of oxidized proteins with GLS (r = 0.386, p = 0.006) and LVEDP (r = 0.389, p = 0.005); we also found a negative correlation of EC-SOD activity with GLS (r = -0.404, p = 0.004) and LVEDP (r = -0.347, p = 0.014).
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Moreno-Ruíz et al. (2015) conducted a case-control in Essential hypertension (n=50). Essential hypertension vs. Age and gender-matched controls was evaluated on Left ventricular global longitudinal strain (GLS) (p=<0.05). Essential hypertension was associated with increased oxidative stress, higher LVEDP (16.2 vs 11.3 mm Hg), and reduced GLS (-12% vs -16%), which significantly correlated with oxidative markers.
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