Key result
Open cardiac surgery with cardiopulmonary bypass led to significant perioperative increases in MR-proADM, MR-proANP, hs-CRP (2.5 to 208 mg/L), and sP-selectin.
Why the study?
For many biomarkers in cardiac surgery, knowledge regarding the normal dynamics of plasma levels during the perioperative course is lacking.
What are the perioperative dynamics of MR-proADM, MR-proANP, hs-CRP, and sP-selectin in patients undergoing open cardiac surgery with CPB?
Observational (n=20)
What are the perioperative dynamics of MR-proADM, MR-proANP, hs-CRP, and sP-selectin in patients undergoing open cardiac surgery with CPB?
This study maps the normal perioperative dynamics of MR-proADM, MR-proANP, hs-CRP, and sP-selectin in patients undergoing cardiac surgery with CPB, providing a baseline for future clinical research.
Defines normal perioperative biomarker kinetics after CPB surgery; hypothesis-generating for future prognostic or therapeutic studies.
Background: For many biomarkers in cardiac surgery, there is a lack of knowledge regarding the normal dynamics of plasma levels during the perioperative course. The aim of this study was to investigate the perioperative dynamics of MR-proADM, MR-proANP, hs-CRP and sP-selectin in cardiac surgery.Method: A prospective observational pilot study with 20 patients scheduled for open cardiac surgery procedures with cardiopulmonary bypass (CPB). Plasma samples were taken for each patient and biomarker during the pre-, per- and postoperative period until Day 6 postoperatively.Results: MR-proADM increased significantly from 0.62 [IQR; 0.54–0.93] nmol/L preoperatively to 1.20 [1.04–1.80] nmol/L postoperative Day 1. MR-proANP increased significantly from 125 [77–152] pmol/L preoperatively to 198 [168–307] pmol/L on weaning from CPB. hs-CRP increased significantly from 2.5 mg/L [0.4–12] preoperatively to peak at 208 mg/L [186–239] postoperative Day 3. The preoperative level of sP-selectin at 23.0 [21.3–26.3] ng/mL initially fell at weaning from CPB, followed by a significant peak of 25.5 [22.7–27.7] ng/mL 8 h postoperatively.Conclusions: The findings in this study may help to understand the physiology of the biomarkers analysed and their response to cardiac surgical trauma including CPB. Furthermore, these findings will guide us in further research on the clinical usefulness of these biomarkers.
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Holm et al. (2020) conducted an observational in Open cardiac surgery with cardiopulmonary bypass (n=20). Open cardiac surgery with cardiopulmonary bypass was evaluated on Perioperative dynamics of MR-proADM, MR-proANP, hs-CRP and sP-selectin. Open cardiac surgery with cardiopulmonary bypass led to significant perioperative increases in MR-proADM, MR-proANP, hs-CRP (2.5 to 208 mg/L), and sP-selectin.
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