Elective cardiac surgery induced a significant increase in serum SAA at 24 hours (232.65 vs 81.1 at baseline, p<0.0001) and HBP at 7 days, with SAA remaining elevated at 3 months.
Cohort (n=99)
Do novel inflammatory markers (HBP and SAA) demonstrate prolonged elevation compared to traditional markers following elective cardiac surgery?
Novel inflammatory markers, particularly SAA, remain elevated up to 3 months after elective cardiac surgery, suggesting prolonged postoperative inflammation not captured by traditional markers.
Absolute Event Rate: 232.65% vs 81.1%
p-value: p=<0.0001
Variability in novel inflammatory markers (HBP and SAA) post-surgery could indicate ongoing perioperative inflammation. This pilot cohort study collected blood from 99 patients undergoing elective cardiac surgery at baseline, 24 hours, 7 days, and 3 months post-surgery. Inflammatory markers (HBP, SAA, PCT, CRP, IL-6) were measured with a point-of-care device. Demographic and clinical data were extracted from health records. Serum SAA increased significantly in the acute postoperative phase (M e IQR;SAA baseline =81.187 vs SAA 24hr= 232.6588.02;U72=2343,p<0.0001), remained elevated at 7 days (Me 7d =252.688.56;U57=1484,p<0.0001) and were still more pronounced than baseline at t 3m (Me 3m =118.44101.52;U38=448,p=0.0008). HBP showed a significant rise at seven days (HBP baseline =4526;89 vs HBP 7d =12169.75;224.5; U56=805,p<0.0001) then returned to near baseline by t 3m (Me 3m =32.515.75;98.5). Traditional inflammatory markers PCT, CRP, and IL-6 demonstrated a rapid increase at t 24h and plateaued at t 7d . None of the biomarkers showed variability at baseline or postoperatively with preoperative status or postoperative complications. Cluster analysis of the inflammatory markers at 24 hours (t 24h ) identified distinct subgroups. Cluster #1-patients with a modest increase in all markers; Cluster#2 characterized with a robust increase in IL-6; Cluster #3 showed increase in CRP and decline in HBP; Cluster #4 showed a modest increase in IL-6 and decline in HBP; Cluster #5 represented a decline in both CRP and SAA. Patients in these clusters differ with respect to age, pre-existing peripheral artery disease, and borderline differences in perioperative acetaminophen use. SAA and HBP remain elevated longer than IL-6, CRP, and PCT after surgery, suggesting that inflammation may persist beyond 3 months.
Laudański et al. (Wed,) conducted a cohort in Elective cardiac surgery (n=99). Elective cardiac surgery vs. Baseline (pre-surgery) was evaluated on Serum SAA levels at 24 hours post-surgery (p=<0.0001). Elective cardiac surgery induced a significant increase in serum SAA at 24 hours (232.65 vs 81.1 at baseline, p<0.0001) and HBP at 7 days, with SAA remaining elevated at 3 months.
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