What question did this study set out to answer?

Quantify and compare the allergen potencies, major allergen concentrations, and total protein contents of commercially available house dust mite sublingual immunotherapy reagents.

January 1, 2015Allergy Asthma and Immunology ResearchOpen Access

In Vitro Evaluation of Allergen Potencies of Commercial House Dust Mite Sublingual Immunotherapy Reagents

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Authors

KPKyung Hee ParkHannam University MSMina SonGeorge Mason University SCSoo-Young ChoiSunchon National University

Discussion

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Implication

In vitro comparative analysis reveals marked potency disparities across commercial house dust mite sublingual immunotherapy formulations, indicating a need for standardized dosing.

Key Points

Quantify and compare the allergen potencies, major allergen concentrations, and total protein contents of commercially available house dust mite sublingual immunotherapy reagents.
Evaluated maintenance dosages of three sublingual immunotherapy reagents (Staloral, SLITone, and Wolwopharma) alongside one subcutaneous immunotherapy reagent (Hollister-Stier).
Measured total protein concentration, Dermatophagoides farinae and Dermatophagoides pteronyssinus group 1 and 2 major allergens via two-site ELISA, and allergen potency via IgE ELISA inhibition assays.
Staloral contained 132.03 µg/mL of group 1 major allergens (33- to 44.5-fold higher than SLITone at 4.00 µg/mL and Wolwopharma at 2.97 µg/mL) and 15.7 µg/mL of group 2 allergens (8.9- to 10.5-fold higher than SLITone at 1.8 µg/mL and Wolwopharma at 1.5 µg/mL).
Wolwopharma total protein content was 1.5- to 261.4-fold higher than that of the other two sublingual reagents.
Specific IgE ELISA inhibition assays demonstrated that the allergen potency of Staloral was 8.5-fold higher than SLITone and 21-fold higher than Wolwopharma.

Cite This Study

Park et al. (2015) studied this question.

synapsesocial.com/papers/6a9e67ea6dfa5258fec3ccca https://doi.org/10.4168/aair.2015.7.2.124

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Implication

In vitro comparative analysis reveals marked potency disparities across commercial house dust mite sublingual immunotherapy formulations, indicating a need for standardized dosing.

In Vitro Evaluation of Allergen Potencies of Commercial House Dust Mite Sublingual Immunotherapy Reagents

Discussion

Member takes

Implication

Key Points

Cite This Study

In Vitro Evaluation of Allergen Potencies of Commercial House Dust Mite Sublingual Immunotherapy Reagents

Discussion

Member takes

Implication

Key Points

Cite This Study

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