Key result
Low average systolic blood pressure (<125 mm Hg) during the first 48 hours after acute myocardial infarction was an independent predictor of 1-year cardiovascular mortality (OR 1.91; 95% CI 1.07-3.41).
Why the study?
Optimal blood pressure in elderly patients after acute myocardial infarction remains a matter of debate.
Does low average systolic blood pressure (<125 mm Hg) during the first 48 hours after admission increase the risk of 1-year cardiovascular mortality in elderly patients (>75 years) with acute myocardial infarction?
Population
814 patients aged >75 years admitted for acute myocardial infarction and discharged alive
Comparison
Average SBP <125 mm Hg vs ≥125 mm Hg over the first 48 hours after admission
Design
Prospective observational study
Follow-up
1-year
Authors
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Low early post-MI SBP signals higher 1-year mortality risk but should not yet change practice; hypothesis-generating and needs prospective validation.
Observational (n=814)
Does low average systolic blood pressure (<125 mm Hg) during the first 48 hours after admission increase the risk of 1-year cardiovascular mortality in elderly patients (>75 years) with acute myocardial infarction?
Odds Ratio: 1.91 (95% CI 1.07–3.41)
Absolute Event Rate: 12% vs 6.6%
p-value: p=0.008
In elderly patients (>75 years) surviving an acute myocardial infarction, an average systolic blood pressure <125 mm Hg during the first 48 hours is a strong, independent predictor of 1-year cardiovascular mortality.
Mouhat et al. (2020) conducted an observational in Acute myocardial infarction (n=814). Low average systolic blood pressure (<125 mm Hg) vs. Average systolic blood pressure ≥125 mm Hg was evaluated on 1-year cardiovascular mortality (OR 1.91, 95% CI 1.07-3.41, p=0.008). Low average systolic blood pressure (<125 mm Hg) during the first 48 hours after acute myocardial infarction was an independent predictor of 1-year cardiovascular mortality (OR 1.91; 95% CI 1.07-3.41).
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