Key result
Early maternal intake of high-dose paracetamol and selective serotonin reuptake inhibitors caused discordant premature ductus arteriosus closure in a twin pregnancy.
Highlights the potential risk of premature ductus arteriosus closure associated with maternal use of high-dose paracetamol and SSRIs during pregnancy.
Raises caution for combined high-dose paracetamol and SSRI use in early pregnancy; leaves open causality and generalizability from this single twin case.
Prenatal DA closure due to early maternal intake of high-dose paracetamol and selective serotonin reuptake inhibitors. MC twin pregnancy uncomplicated by TTTS with discordant prenatal DA closure.
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Corti et al. (2020) studied this question. Early maternal intake of high-dose paracetamol and selective serotonin reuptake inhibitors caused discordant premature ductus arteriosus closure in a twin pregnancy.
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