Key result
Maternal diclofenac therapy at 35 weeks of gestation led to premature closure of the ductus arteriosus, requiring immediate Cesarean section for an excellent neonatal outcome.
Population
1 fetus at 37 weeks of gestation whose mother received diclofenac therapy at 35 weeks of gestation
Design
Case_report
Authors
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May signal third-trimester diclofenac risk to fetal ductus; leaves open need for prospective NSAID safety data.
Case Report (n=1)
Maternal use of diclofenac in the third trimester can cause premature closure of the fetal ductus arteriosus and should be avoided.
Auer et al. (2004) conducted a case report in Premature closure of the ductus arteriosus (n=1). Maternal diclofenac therapy was evaluated on Fetal echocardiographic findings and neonatal outcome. Maternal diclofenac therapy at 35 weeks of gestation led to premature closure of the ductus arteriosus, requiring immediate Cesarean section for an excellent neonatal outcome.
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